中文摘要：

P-糖蛋白和细胞色素CYP450酶为体内重要的转运蛋白和代谢酶,参与药物在体内的吸收和代谢.千金子对胃肠道有强烈的刺激作用,可以产生峻泻,本文将从P-糖蛋白和CYP450酶功能着手分析二者对千金子肠道毒性的影响,为千金子肠道毒性的研究提供新的思路和方法.

英文摘要：

P- glycoprotein and cytochrome CYP450 enzymes are important transporters and metabolic enzymes in the body, and their play an important role in absorption and metabolism of drugs. Euphorbia lathyris has strong stimulation to the gastrointestinal tract j can induce seriously diarrhea. This article focused on the functions of P - glycoprotein and cytochrome CYP450 enzymes to analyze the reason why Euphorbia lathyris could lead to intestinal toxicity, and provided a new idea and method to reseai＇ch the intestinal toxicity of Euphorbia lathyris.