中文摘要：

目的：合成红景天苷类似物,并初步分析评价对2,2-二苯基苦基苯肼自由基（DPPH）的清除能力。方法：以O-乙酰基溴代葡萄糖、O-乙酰基溴代半乳糖为供体,以苯甲醇、苯乙醇取代物为糖配体合成红景天苷类似物。采用微孔板定量法分析测定其对DPPH的清除能力。结果：合成了9个目标化合物,确定其在清除DPPH·反应达到50%时的IC50（μgDPPH·/ml）。结论：所合成类似物皆具有一定的清除DPPH·的能力,尤其是化合物1-（4-羟基苯基）甲基-β-D-葡萄糖苷和1-（4-羟基苯基）甲基-β-D-半乳糖苷,其IC50分别为4.57μg/ml,5.15μg/ml,优于阳性对照维生素C（IC50：12.32μg/ml）,显示有很好抗氧化能力。

英文摘要：

Objective：To synthesize salidroside analogues and preliminarily evaluate the free radical scavenging activities by 2,2-diphenyl-1-picrylhydrazyl（DPPH）.Methods：The synthesis started from O-acetobrome-sugar（glucose and galactose） as donor and substituents of benzyl alcohol and phenylethyl alcohol as aglycone,microplate quantification of DPPH was used to evaluate scavenging capability.Results：Nine target compounds were synthesised,the IC50（μg DPPH/ml） of which were afforded.Conclusion：The synthesized analogues all had the efficiency of scavenging DPPH radical,especially 4-hydrobenzyl-β-D-glucopyranoside and 4-hydrobenzyl-β-D-galactopyranoside displayed good antioxidant capacity,and IC50 were 4.57μg /ml and 5.15μg /ml,respectively,superi-or to positive control VC（IC50：12.32μg /ml）.