中文摘要：

肺癌和慢性阻塞性肺病（COPD）是全球高死亡率的疾病。流行病学研究表明，COPD可增加患肺癌的风险。COPD和肺癌皆可由吸烟引起，且这两种疾病常常发生在同一患者身上。但两种疾病之间的联系不仅仅是吸烟，其病理机制联系还包括遗传易感性、炎症反应、细胞损伤、氧化与毒性应激、细胞外基质和蛋白酶的分泌等。其中的一些共性可能成为这两种疾病的化学预防或化学治疗的靶点。

英文摘要：

Lung cancer and chronic obstructive pulmonary disease （COPD） are two high-mortality dis- eases in the world. Numerous epidemiological studies have demonstrated that presence of COPD increases the risk of lung cancer. Habitual cigarette smoking frequently develops lung cancer as well as COPD, However the links between the two diseases should be more than smoking alone. The underlying mechanisms may include genetic predisposition, inflammation and cell injury, oxidative and noxious stress, extracellular matrix and pro- teinases, some of which might represent the targets for chemoprevention or chemotherapy.