为了寻找有生物活性的次生代谢产物,对从采集自中国南海的软海绵(Halichondria sp.)进行了化学成分研究,从中共分离得到了9个化合物,并对部分化合物进行了抗菌活性测试。根据现代波谱技术并结合文献数据,鉴定化合物的结构为:1,2,3,4-四氢-3-羧基-2-卡波林(1),色氨酸(2),环(异亮氨酸-脯氨酸)(3),开环(脯氨酸-缬氨酸)(4),环(丙氨酸-脯氨酸)(5),胆甾醇(6),二-(2-乙基己基)邻苯二甲酸酯(7),邻苯二甲酸正丁异丁酯(8)和邻苯二甲酸二异丁酯(9)。
Nine known compounds were isolated from the South China Sea sponge Halichondria sp. and the antibacterial activities of compounds 1-6 were tested. Their structures were identified as 1,2,3,4-tetrahydro-3-carboxy-2-carboline (1) ,tryptophan (2),cyclo-(Ile-Pro) (3),seco-((S)-Pro-Val) (4),cyclo-(Ala-Pro) (5),cholesterol (6),bis (2- ethylhexyl) phthalate (7), phthalie acid butyl isobutyl ester (8), and 1,2-benzenedicarboxylic acid diisobutyl ester (9) on the basis of detailed spectroscopic analysis and comparison with the data reported in the literature.