中文摘要：

目的：研究南海多室草苔虫（Bugula neritina L.）的甾醇类化学成分。方法：采用乙醇提取,硅胶柱色谱,Sephadex LH-20柱色谱等手段进行分离纯化,通过波谱分析,结合文献对照,鉴定化合物结构。结果：从多室草苔虫石油醚部位分离到10个甾醇类化合物,鉴定为：胆甾-4-烯-3-酮（Ⅰ）;胆甾醇（Ⅱ）;3β,5α,9α-三羟基-（22E,24R）-麦角甾-7,22-二烯-6-酮（Ⅲ）;24-甲基-5α-胆甾-72,2-二烯-3β,56,β-三醇（Ⅳ）;3β-羟基-7-甲氧基-胆甾-5-烯（Ⅴ）;过氧化麦角甾醇（Ⅵ）;3β-羟基-胆甾-5-烯-7-酮（Ⅶ）;6β-羟基-胆甾-4-烯-3-酮（Ⅷ）;胆甾-5-烯-3β,7β-二醇（Ⅸ）;胆甾-5,22（E）-二烯-3β7,α-二醇（Ⅹ）。结论：化合物Ⅴ～Ⅹ为首次从该种多室草苔虫中得到。

英文摘要：

Objective：To study the sterol constituents of Bugula neritina from the South China Sea.Methods：The alcohol extract of Bugula neritina was purified by silica gel column and Sephadex LH-20 column chromatography,and structures of the isolated compounds were identified by spectroscopic analysis and comparison with those of literatures.Results：Ten sterols were isolated and identified from the petroleum ether fraction of alcohol extract of B.neritina L.：Cholest-4-en-3-one（Ⅰ）;cholesterol（Ⅱ）;3β,5α,9α-trihydroxy-（22E,24R）-ergosta-7,22-dien-6-one（Ⅲ）;24-methyl-5α-cholesta-7,22-diene-3β,5,6β-triol（Ⅳ）;3β-Hydroxy-7-methoxy-Cholesta-5-en（Ⅴ）;5α,8α-epidioxy-（22E,24R）-ergosta-6,22-dien-3β-ol（Ⅵ）;3β-hydroxycholest-5-en-7-one（Ⅶ）;and 6β-hydroxy-cholest-4-en-3-one（Ⅷ）;Cholesta-5-ene-3β,7β-diol（Ⅸ）;Cholesta-5,22（E）-dien-3β,7α-diol（Ⅹ）.Conclusion：Compounds Ⅳ~Ⅹ were isolated from Bugula neritina for the first time.