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A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases
  • ISSN号：1671-4083
  • 期刊名称：《中国药理学报：英文版》
  • 时间：0
  • 分类：R692[医药卫生—泌尿科学;医药卫生—临床医学;医药卫生—外科学] R587.1[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构：[1]Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 210203, China
  • 相关基金：Acknowledgements We are very grateful to Prof Nicholas K TONKS （Cold Spring Harbor Laboratory, NY, USA） for supplying the TC45 vector, to Prof Rafael PULIDO （Centro de Investigacion Principe Felipe, Valencia 46013, Spain） for providing the pGEX2T-CD4S （aa 560-1256）, to Prof Frank RJIRIK （University of British Columbia, Vancouver, British Columbia VSZ 4H4, Canada） for providing the pGEX2T-PTPα vector, and to ProfYan CHEN （Institute of Nutritional Sciences, Shanghai, China） for supplying the 3T3-LI cell. This work was supported by the State Key Program of Basic Research of China （grants 2004CB518905 and 2007CB914304）, the National Natural Science Foundation of China （grants 30525024, 90713046, 20721003, and 20772136）, and Foundation of Chinese Academy of Sciences （grant KSCX2-YW-R- 18）.
作者： Yu ZHANG Yan LI Yue-wei GUO Hua-liang JIANG Xu SHEN[1]
关键词： 信号转导通路, 胰岛素治疗, 倍半萜, 蛋白酪氨酸磷酸酶1B, 海绵, 激活, WESTERN印迹, 3T3细胞, sesquiterpene quinone, dysidine, PTPIB, inhibitor, insulin
中文摘要：

These two authors contributed equally. These two authors contributed equally. Yue-wei GUO.E-mail：ywguo@mail.shcnc ac.cn Xu SHEN E-mail：xshen@mail.shcnc.ac.cn

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期刊信息
  • 《中国药理学报：英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中科院上海药物研究所
  • 主编：丁光生
  • 地址：上海市太原路294号31号楼
  • 邮编：200031
  • 邮箱：
  • 电话：021-54922821 54922822
  • 国际标准刊号：ISSN：1671-4083
  • 国内统一刊号：ISSN：31-1347/R
  • 邮发代号:4-295
  • 获奖情况:
  • 1992、1996年两届全国优秀科技期刊一等奖,1992、1996、1997年中国科协、中科院以及上海市优...,首届国家期刊奖、2000年中科院优秀期刊评比特别奖
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  • 被引量:1239