中文摘要：

目的：探讨桃红四物汤防治缺血性中风的作用并初步阐明其机制。方法：灌胃给予大鼠大、中、小（17.00 g/kg、8.50g/kg、4.25 g/kg）剂量的桃红四物水提物连续15天,采用线栓法复制大脑中动脉栓塞（MCAO）模型,将中动脉闭塞1.5 h再灌注24h后,检测各组大鼠行为学指标,摘眼球取血测定血清中NO2-浓度,取全脑切片后TTC染色检测脑梗死面积,取梗死区域脑提取mRNA检测神经元型一氧化氮合酶（nNOS）表达情况。结果：17.00 g/kg、8.50 g/kg、4.25 g/kg的桃红四物水提物均能改善行为学评分,与模型组比较差异具有显著性意义;17.00 g/kg、4.25 g/kg的桃红四物水提物能升高MCAO模型大鼠血清中NO2-浓度,与模型组比较差异具有显著性意义;17.00 g/kg、8.50 g/kg、4.25 g/kg的桃红四物水提物均能减小MCAO大鼠的脑梗死面积,与模型组比较差异具有显著性意义;17.00 g/kg、4.25 g/kg的桃红四物水提物能恢复MCAO模型大鼠梗死区域脑内的nNOS表达,与模型组比较差异具有显著性意义。结论：桃红四物水提物能减轻MCAO大鼠脑缺血再灌注损伤,减少脑梗死面积,同时改善模型大鼠的行为学评分。

英文摘要：

Objective ：Study on the effects of Taohongsiwu aqueous extract （THSW） on ischemic stroke and expound its mechanisms. Methods： Rats were given 17.00 g/kg, 8.50 g/kg, 4.25 g/kg THSW respectively for 15 days by intragastric administration. Then create middle cerebral artery occlusion （MCAO） model. After blocking middle artery for 1.5 h and reperfusion for 24 h, Behavioral testing, infarct size of brain and NO2 in the serum was tested. Then, extract the total RNA from brain and determine the expression of neuronal nitric oxide synthase （nNOS）. Results： 17.00 g/kg, 8.50 g/kg, 4.25 g/kg THSW could improve behavioral score; 17.00 g/kg, 4.25 g/kg THSW could increase the concentration of NO2 in serum of rats in MCAO model; 17.00 g/kg, 8.50 g/kg, 4.25 g/kg of THSW all could decrease the area of cerebral infarction of rats in MCAO model; 17.00 g/kg, 4.25 g/kg of THSW could recover the expression of nNOS in the area of cere- bral infarction of MCAO rats. Conclusion： THSW can relieve cerebral ischemia-reperfusion injury of brain in MCAO model.