中文摘要：

目的：给小鼠等动物灌服冰片后，对冰片在其体内转化为樟脑的情况进行初步的定性研究。方法：将天然冰片、冰片（合成龙脑）和异龙脑配成混悬液后，给小鼠灌服，30min后处死小鼠，取肝脏和血浆，经过（肝脏匀浆、）萃取、离心等处理后，取上清液注入GC—MS进行定性分析；给小鼠、大鼠、家兔灌服天然冰片后，在不同时间点取样，经处理后对樟脑进行分析。结果：GC—MS法可很好的分离和定性龙脑、异龙脑和樟脑等成分；小鼠灌服天然冰片、冰片（合成龙脑）和异龙脑后30min，小鼠体内均检测到樟脑色谱峰；灌服天然冰片后在不同动物体内樟脑的含量基本都随着时间的延长而呈一定规律性的变化。结论：冰片（天然冰片、冰片（合成龙脑））和异龙脑在小鼠、大鼠、家兔体内有转化为樟脑的趋势，动物体内的樟脑含量随时间而呈规律性变化。

英文摘要：

This is a study to understand the biotransformation of borneol to camphor in mice, rats, and rabbits. We administered a single oral dose （1.0 g/kg） of natural borneol to mice, and sacrificed them 0.5 hr. later. Plasma and liver sampies were removed from the mice, and analyzed for both borneol and camphor using GC-MS. The study was repeated with isoborneol and synthetic borneol. In a separate study, a suspension of natural borneol in 0.8%CMC-Na was administered to mice, rats, and rabbits. Blood samples were removed from the animals at different time points post-dosing, and analyzed for camphor using GC-MS. Study results show that a mixture of borneol, isoborneol, and camphor was well separated by the GC-MS method. Camphor was present in both the plasma and liver of mice after pretreatment with natural borneol, synthetic borneol, or isoborneol. Plasma camphor concentration was also found to increase with time in mice, rats, and rabbits, after receiving natural borneol. We conclude that camphor appears to be a common metabolite of natural borneol, synthetic borneol, and isoborneol in mice, rats and rabbits.