中文摘要：

目的 探讨负荷剂量瑞舒伐他汀对不稳定型心绞痛（UAP）患者经皮冠状动脉介入治疗（PCI）术后炎症因子的影响.方法 选择我院住院的UAP患者68例,随机分为对照组（术前不予瑞舒伐他汀,术后给予10 mg/d,n=34）和强化瑞舒伐他汀组（术前2 d给予20 mg/d,术后给予10 mg/d,n=34）.分别于PCI术前、术后18～24 h检测心肌损伤标志物cTnI、CK-MB以及超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、血清干扰素-γ（IFN-γ）等炎症因子的表达.结果 ①PCI术后18～24 h,强化瑞舒伐他汀组患者cTnI高于正常高值的发生率低于对照组（P〈0.05）.术后CK-MB两组比较差异无统计学意义（P〉0.05）.②PCI术后18～24 h,hs-CRP、TNF-α、IFN-γ均较术前进一步升高,对照组较强化瑞舒伐他汀组升高明显,两组各项指标比较差异有统计学意义（P〈0.05）.结论 PCI术前给予20 mg瑞舒伐他汀可以有效地降低炎症因子hs-CRP水平及术后心肌损伤的发生率.

英文摘要：

Objective To investigate the effects of loading - dose rosuvastatin on inflammatory cytokines from unstable angina patients after percutaneous coronary intervention （PCI）. Methods A total of 68 unstable angina patients were enrolled. Unstable angina patients were randomized to control group （ n = 34） or pretreatment with loading - dose rosuvastatin group （20 rag/d, n = 34）. cTnI, CK - MB, hs- CRP, TNF-αand IFN -γ were measured respectively before PCI and 18 -24 h post PCI. Results （1）Compared with control group, rosuvastatin effectively reduced cTnI elevating after PCI （P 〈 0.05）. The CK- MB level was not statistically different between the two groups after PCI（ P 〉0.05 ）. @）The serum levels of hs - CRP, TNF -α and IFN -γ were all increased in both groups after PCI. However, levels of hs - CRP, TNF --α and IFN -γ in control group were higher than those in rosuvastatin group after PCI （ P 〈 0. 05 ）. Conclusion Loading - dose rosuvastatin （ 20 mg ） pretreatment can reduce post- PCI myocardial inflammation and periprocedural myocardial injury effectively.