中文摘要：

目的 探讨曲美他嗪对不稳定型心绞痛患者经皮冠状动脉介入治疗（PCI）围术期炎性因子的影响.方法 入选2011年3月-2013年3月在我院住院的不稳定型心绞痛患者78例,按随机数字表法分为对照组（不予曲美他嗪,n=39）和曲美他嗪组（术前5 d给予曲美他嗪20 mg,3次/d,术后坚持服用曲美他嗪20 mg,3次/d,n=39）.分别于PCI前及PCI后18~24 h检测心肌损伤标志物肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK-MB）及超敏C反应蛋白（hs-CRP）、干扰素γ（IFN-γ）和白介素2（IL-2）等炎性因子的表达水平.结果 PCI后曲美他嗪组患者cTnI水平高于参考值上限的发生率低于对照组[37.6%（15/39）和56.4%（22/39）,χ2=4.198,P=0.04],但两组PCI后CK-MB水平高于参考值上限的发生率间差异无统计学意义[10.3%（4/39）和12.8%（5/39）,χ2=0.000,P=1.00].PCI后两组hs-CRP、IFN-γ、IL-2水平均较PCI前升高,且对照组较曲美他嗪组升高（P＜0.05）.结论 PCI术前应用曲美他嗪治疗可以有效降低炎性因子hs-CRP、IFN-γ、IL-2水平及PCI后心肌损伤的发生率.

英文摘要：

Objective To investigate the effects of trimetazidine on inflammatory cytokines in unstable angina （UA） patients during perioperative period of pcrcutaneous coronary intervention （PCI）. Methods A total of 78 UA patients hospital- ized in this hospital from March 2011 to March 2013 were divided randomly into groups A （control group） , B （given trimetazi- dine 5 d before surgery, 20 mg, 3 times/d, and after surgery, 20 mg, 3 times/d） , 39 in each. The expressions of myocardial injury markers troponin I （cTnI）, ereatine kinase isoenzyme （CK- MB ） and high -sensitivity C -reactive protein （hs- CRP）, interferon-γ （IFN-γ）, interleukin -2 （IL-2） and other inflammatory eytokines were detected before PCI and 18 -24 h after. Results The incidence of cTnI level above the upper limit of the reference values was lower in group B than in group A after PCI [37. 6% （15/39） vs. 56.4% （22/39）, X2 =4. 198, P =0. 04]. No significant difference was noted in CK-MB level between 2 groups after PCI [10.3% （4/39） vs. 12.8% （5/39）, X2 =0.000, P - 1.001. The levels of hs - CRP, IFN - γ,, IL - 2 were higher after PCI than before, and higher in group A than in group B （P 〈 0. 05）. Conclusion Trimetazidine can reduce the levels of inflammatory cytokines and the incidence of post - operative myocardial injury.