中文摘要：

目的研究经皮冠状动脉介入（PCI）治疗前后血清氧化低密度脂蛋白（ox—LDL）水平的变化情况及其临床意义。方法133例冠心病（CHD）患者根据行PCI与否分为干预组80例及未干预组53例。两组患者均于入院后空腹抽取静脉血，行冠状动咏造影（CAG）或PCI后即刻及PCI术后2d留取静脉血，检查血脂及ox—LDL水平。结果干预组PCI术后ox-LDL水平（86．92±32．85）mg／L较术前（75．38±27．36）mg／L明显升高（P〈0．01），其升高程度在冠状动脉狭窄严重、急性心肌梗死（AMI）及不稳定心绞痛（UA）患者中呈上升趋势，并于术后2d回到术前水平；未干预组则无明显变化。结论CHD患者PCI术后ox-LDL水平可出现短暂升高，提示可能与介入所致粥样斑块破损有关。

英文摘要：

Objective To study the changes of the oxidized low density lipoprntein （ox-LDL） levels before and after percutaneous coronary intervention （ PCI）, and clarify the clinical significance of ox-LDL. Methods One hundred and thirty three patients with coronary heart disease （CHD） were divided into PCI （80） and non-PCI （53） groups. Fasting plasmas of before coronary angiography （CAG） , plasmas immediate after CAG or PCI, and two days after PCI were collected, and the levels of ox-LDL and other lipids were detected. Results The level of ox-LDL in PCI group immediate after PCI was significantly higher than that before PCI [ （86.9 ±32.9） mg/L vs （75.4 ±27.4） mg/L, P 〈0.01 ] , and the extent of the increased level was higher in patients with severe stenosis, AMI, and UA. The level of ox-LDL two days after PCI dropped to the level of before PCI. The ox-LDL level before and after CAG in non-PCI group showed no difference. Conclusion The level of ox-LDL transiently increased markedly after PCI in patients with CHD, which might imply the relation with rapture of atheromatous plaque by intervention.