中文摘要：

目的探讨冠心病患者氧化型低密度脂蛋白（OX—LDL）的变化及机制，评估OX-LDL水平检测的临床价值。方法采用ELISA法测定139例冠心病组患者[急性冠状动脉综合征（ACS）76例，非ACS组63例]和100例健康对照组人群血浆OX-LDL水平；根据冠状动脉造影结果将冠心病组分为多支病变组、双支病变组和单支病变组进行比较分析。结果ACS组患者和非ACS组患者OX-LDL水平均显著高于健康对照组[ACS：（188．01±69．88）μg,／ml，非ACS：（137．88±59．74）μg／ml，对照组：（82．68±29．06）μg／ml；P均〈0．001]；且ACS组患者OX-LDL水平显著高于非ACS组患者（P〈0．001）。冠状动脉多支、双支、单支病变组间OX—LDL水平不同[（183．63±79．42）μg／ml，（164．15±63．79）μg／ml和（146．97±58．40）μg／ml，P〈0．05]，多支高于单支（P〈0．01）。多因素分析显示冠状动脉病变程度仅与OX—LDL相关（R2=0．048，8=0．217，P=0．000）。结论冠心病患者OX—LDL水平升高，与病变程度相关，急性冠脉综合征患者变化尤为显著。

英文摘要：

Objective To explore the changed mechanism of plasma oxidized low-density lipoprotein （ox-LDL） in the patients with coro- nary heart disease, and to evaluate the clinical value of detection for ox-LDL level. Methods Enzyme-linked immunosorbent assay （ELISA） was used to measure the plasma ox-LDL in 139 patients with coronary heart disease, among them 76 were acute coronary syn- drome （ACS） and 63 were non-ACS patients, and in 100 healthy controls. The patients were divided by coronary angiography into multi-vessel disease group, double-vessel disease group and mono-vessel disease group. Results The ox-LDL levels of the patients in both ACS and non-ACS groups[ （188.01±69.88）μg/ml and （137.88±59.74） μg/ml] were significantly higher than that in nor- mal controls group[ （82.68 ± 29.06 ） μg/ml ;P 〈 O. 001 ], and the ox-LDL level of patients in ACS group was significantly higher than that in non-ACS group （ P 〈0. 001 ）. Different plasma levels of ox-LDL were found in the multi-vessel, double-vessel and mono-vessel disease group [ （ 183.63± 79.42） μg/ml, （ 164.15± 63.79） μg/ml, and （ 146.97 ± 58.40） μg/ml, respectively, P 〈 0.05 ]. The ox-LDL levels in multi-vessel disease group were significantly higher than that in mono-vessel group （ P 〈 0.01 ）. Multiple linear re- gression analysis showed that ox-LDL levels significantly correlated with the severity of coronary artery disease （ R2 = 0. 100,13 = 0. 316 ,P =0.000）. Conclusion Elevated levels of ox-LDL presented in the patients with coronary heart disease and correlated with the severity of coronary artery lesion, especially in the patients with acute coronary syndrome.