中文摘要：

目的探讨急性冠状动脉综合征（ACS）患者血浆氧化脂蛋白（a）[ox—Lp（a）]水平的变化及机制。方法分别检测96例ACS、89例非ACS患者和100例健康人血浆ox—Lp（a）水平，冠状动脉造影确认冠状动脉病变程度。结果ACS组和非ACS组ox—Lp（a）水平均高于对照组，且ACS组ox—Lp（a）水平显著高于非ACS组。ACS组ox—Lp（a）／Lp（a）比值高于非ACS组和健康对照组，后两者ee该比值无显著差别。ACS患者中ox—Lp（a）水平与冠状动脉病变程度相关（r=0．370，P=0．000），非ACS组中两者不相关（r=0．051，P=0．634）。多因素分析显示，ox—Lp（a）、TG水平及年龄解释ACS患者15．1％的病变程度。结论高ox—Lp（a）水平与ACS的发生、病变程度有关，有益于鉴别ACS。

英文摘要：

Objective To investigate the association of increased oxidized lipoprotein（a） [ ox-Lp（a） ] levels with the severity of acute coronary syndromes （ACS） and relevant possible mechanisms. Methods Ox-Lp （a） levels were measured in 96 ACS patients, 89 non-ACS patients, and 100 healthy subjects. The extent of coronary artery disease （CAD） was determined by coronary angiography. Results Ox-Lp（a） levels significantly increased in ACS or non-ACS patients, compared with those in control. ACS patients had higher ox-Lp（a） levels than non-ACS patients. The ratio of ox-Lp（a） to Lp（a） in ACS was higher than that in either non-ACS or control, whereas the ratio was comparable between the non-ACS and control. Ox-Lp （a） levels were found to be associated with a graded increase with the severity of CAD in the ACS （ r = 0. 370, P =0. 001 ）, yet not in the non-ACS （ r = 0.051, P = 0.634）. Multiple linear regression analysis showed that ox-Lp（ a）, triglyceride, and age accounted for 15.1% of the variation in the severity of CAD in ACS patients. Conclusions Elevated ox-Lp（a） levels are associated with the presence and severity of ACS, and testing ox-Lp （a） may be useful in identifying ACS patients.