中药功效相关的多成分、多靶点、多环节之间组成了密切联系、相互协同与制约的复杂网络,发现这一复杂网络的内在联系,揭示各成分间相互协同的机理,明确这一复杂作用关系的整体效应,对于基本清楚中药的物质基础和作用机理具有关键作用,是中药学理论与现代研究成果相融合的基本途径。本文探讨了中药功效网络的基本概念,提出中药功效网络的三个层次,分别为中药功效的分子网络、模块网络和概念网络。提出中药功效网络构建的三种基本途径,分别为基于中药作用靶点辨识、基于药理指标相关作用环节和基于中医理论与中药基本信息的网络构建,并以活血化瘀功效网络为例探讨了中药功效网络可能的应用途径。
Study the complex network of TCM functionalities, including its multi-components, multi-targets, and muhi-links, is important for understanding the substances and mechanisms of TCM, and its possible integration with the modern findings in the area. This paper discusses the basic concepts and types of TCM function networks, along with the methods for building the networks. Using the prescription of Promoting Blood Circulation and Removing Blood Stasis as an example, authors examine the possible applications of TCM function networks. The concept and techniques discussed in the paper create a ground for the further development of both TCM theories and practices.