中文摘要：

目的评价c-Met蛋白在乳腺癌中的表达状况及与临床病理指标的可能关系。方法采用免疫组织化学方法检测100例乳腺浸润性导管癌c-Met蛋白的表达,并评价它们与病理分级、临床分期、转移以及预后之间的关系。结果 100例乳腺癌组织c-Met表达阳性43例,阴性57例。c-Met的表达与乳腺癌淋巴结转移（P=0.0001）、临床分期（P=0.001）以及预后（P=0.009）密切相关;与年龄（P=0.784）、肿瘤大小（P=0.890）和肿瘤病理分级（P=0.456）无关。结论 c-Met的表达在乳腺癌中有统计学意义,其表达随转移和临床分期升高而增强,提示其对乳腺癌的发生及侵袭、转移起着重要作用。

英文摘要：

Objective To clarify the clinicopathological significance of expression of c-Met protein in invasive breast ductal carcinoma.Methods The expression of c-Met protein in the 100 samples was detected by non-biotin immunohistochemical method,the expression of positive cells for c-Met protein was evaluated,and its association with histological grade,lymphatic metastasis,TNM stage and prognosis was assessed.Results The expression of c-Met protein was positive in 43（43.0%）of 100 invasive breast ductal carcinomas.The positive expression of c-Met protein was significantly corresponding to lymph node metastasis（P=0.0001）,TNM stage（P=0.001）and prognosis（P=0.009）and but not to age（P=0.784）,tumor size（P=0.890）and histological grade（P=0.456）.But c-Met was not an independent prognostic factor（P=0.072）.Conclusions The expression of c-Met protein may play an important role with neoplastic progression in invasive breast ductal carcinoma.Expression of c-Met might be associated with aggressive tumor phenotype of invasive breast ductal carcinoma.The expression of c-Met may be a useful prognostic indicator.