中文摘要：

目的探讨小泛素样修饰蛋白4（SUMO4）基因163A/G多态性与2型糖尿病（T2DM）和糖尿病视网膜病变（DR）的相关性.方法运用聚合酶链反应-限制性片段长度多态性技术,在昆明地区汉族人中对193例2型糖尿病患者（T2DM组）和102例健康对照者（NC组）的SUMO4基因163A/G多态性进行检测,并比较各组间基因型频率和等位基因频率以及相关临床资料.结果 NC组与T2DM组各基因型和等位基因频率无统计学差异;DR组与DR0组各基因型和等位基因频率也无统计学差异.结论在昆明地区汉族人群中,SUMO4基因163A/G多态性可能不是2型糖尿病和糖尿病视网膜病变发生的危险因素.

英文摘要：

Objective To investigate the association of 163 A/G polymorphism of SUMO4 gene with diabetic retinopathy.Methods The polymorphism of SUMO4 gene 163 A/G was detected by PCR-RFLP in 193 unrelated Kunming Han patients with type 2 diabetes,and 102 normal controls. The genotype,allele frequencies and relative clinic data were compared between two groups.Result There were no significant differences in genetype and allele frequencies between NC group and T2DM group and between DR and DRO group. Conclusion The SUMO4 gene 163 A/G polymorphism maybe not associated with diabetic retinopathy in Kunming Han people.