中文摘要：

目的探讨肝脏受控衰减参数（CAP）与代谢综合征（MetS）之间的相关性，并探讨CAP值及其变化幅度与MetS发病率的关系。方法纳入2013年7月至2015年9月的健康体检人群2461名。Spearman相关分析CAP与MetS组分个数及各组分之间的相关性，x^2检验比较不同CAP水平下MetS及各组分的患病率。Logistic回归分析不同CAP水平人群发生MetS的比值比及其95％可信区间。选取230名基线无MetS者，通过前瞻性队列研究，根据基线CAP值、CAP变化值以及CAP变化值百分比分组进行x^2检验，比较MetS的发病率。COX回归分析基线CAP、CAP变化值以及CAP变化值百分比对MetS的预测作用。结果CAP与MetS组分个数呈正相关（r=0．309，P〈0．01），与各组分均显著相关。不同CAP水平下（〈238dB／m、238～258dB／m、259～291dB／m和≥292dB／m）MetS及其各组分的患病率差异存在统计学意义（尸〈0．05）。调整性别、年龄后，以〈238dB／m为参照，238～258dB／m、259～291dB／m和≥292dB／m的人群发生MetS的比值比及其95％可信区间分别为1．784（1．369～2．325）、2．936（2．292～3．760）和4．363（3．435～5．543），P值均〈0．05。随访结束时28例（12．2％）发生MetS。调整相关因素后，基线CAP≥238dB／m、CAP变化值〉30dB／m和CAP变化值百分比〉25．0％的人群MetS发病的风险比及其95％可信区间分别为3．337（1．163～9．569）、7．732（2．453～24．366）和11．656（3．329～40．813），尸值均〈0．05。结论CAP与MetS及其各组分密切相关，CAP及其变化幅度可用于预测MetS的发生风险。

英文摘要：

Objective To investigate the association between hepatic controlled attenuation parameter （CAP） and metabolic syndrome （MetS） and the correlation of CAP and its changes with the incidence of MetS. Methods A total of 2461 subjects who underwent physical examination from July 2013 to September 2015 were enrolled. Spearman correlation analysis was used to investigate the correlation of CAP with the number of MetS components and each MetS component, and the chi-square test was used to investigate the prevalence rates of MetS and each component under different CAP levels. Logistic regression analysis was used to analyze the odds ratio （95% confidence interval （CI）） of MetS under different CAP levels. A total of 230 subjects without baseline MetS were selected; in a prospective cohort study, these subjects were divided into groups according to the baseline CAP, change in CAP, and percent change in CAP, and the chi-square test was performed to compare the incidence of MetS. The Cox regression analysis was used to analyze the values of baseline CAP, change in CAP, and percent change in CAP in predicting MetS. Results CAP was positively correlated with the number of MetS components （r = 0.309, P 〈 0.01） and significantly correlated with all components. There were significant differences in the prevalence rates of MetS and its components under different CAP levels （〈 238 dB/m, 238-258 dB/m, 259-291 dB/m, and ≥ 292 dB/m） （P 〈 0.05）. After the adjustment for sex and age, with 〈 238 dB/m as a reference, the odds ratios （95% CI） of MetS in patients with CAP levels of 238-258 dB/m, 259-291 dB/m, and ≥ 292 dB/m were 1.784 （1.369-2.325）, 2.936 （2.292-3.760）, and 4.363 （3.435-5.543）, respectively （allP 〈 0.05）. Follow-up data showed that 28 patients （12.2%） developed MetS. After the adjustment for related factors, the hazard ratios （95 % C/） of MetS in patients with baseline CAP 〉 238 dB/m, change in CAP 〉 30 dB/m, and percent change in CAP 〉 25.0% were 3.