中文摘要：

在短暂的外面的钾水流上学习 allitridum 的效果(我 _{到在心失败(HF ) 的室的 myocytes 的} ).MethodsThe 双酶的方法被用来把单个室的 myocytes 与 Sprague Dawley 老鼠分开。夹钳补丁习惯于记录我 _到 和分析 current.ResultsThe 上的 allitridum 的效果我 _到 ，电流在 HF 组有重要减少，与控制组相比。密度我 _{到在 HF 的} ，组在 allitridum 的处理以后被增加(30 ????????? 佐 ??? 啓位 ??? 潃据畬楳湯即偎？？

英文摘要：

Objective To study the effect of allitridum on the transient outward potassium current （Ito） of ventricular myocytes in heart failure （HF）. Methods The dual enzymatic method was used to separate single ventricular myocytes from Sprague Dawley rats. Patch-clamping was used to record Ito and analyze the effect of allitridum on the current. Results The Ito current had a significant decrease in the HF group, compared with the control group. The density of Ito in the HF group was increased after treatment of allitridum （30 μmol/L）. The peak current densities of Ito were enhanced in the HF group from 6.01 ±0.30 pA/pF to 8.41 ±0.54 pA/pF （P 〈 0.01） at ＋50 mV after treatment with allitridum （30 μmol/L）. We also determined the effect of allitridum on the gating mechanism of the Ito in the HF group. Conclusions We found that allitridum increased the Ito by accelerating the activation of channels and shortened the time constants of inactivation, and allitridum decreased the remodeling of Ito in ventricular myocytes of rats with HF.