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大蒜素对自发性高血压大鼠心肌I_（to）重构的影响
  • ISSN号：0513-4870
  • 期刊名称：《药学学报》
  • 时间：0
  • 分类：R[医药卫生]
  • 作者机构：[1]Department of Cardiology, Chinese PLA General Hospital, Beijing, China, [2]Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • 相关基金：Acknowledgments This work was supported by the National Natural Science Foundation of China （No： 81170177, 81030002 and 8147054）. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There is no competing interest to declare.
作者： 但晴[1], 赵颖[1], 吴志娟[1], 朱超[1], 刘丽[1], 徐斌[1], 刘昱圻[1], 陈琪[1], 李泱[1]
关键词： Allitridum, 心失败, 离子电流, 室的, myocyte, Allitridum, Heart failure, Ion current, Ventricular myocyte
中文摘要：

在短暂的外面的钾水流上学习 allitridum 的效果(我 到在心失败(HF ) 的室的 myocytes 的 ).MethodsThe 双酶的方法被用来把单个室的 myocytes 与 Sprague Dawley 老鼠分开。夹钳补丁习惯于记录我 到 和分析 current.ResultsThe 上的 allitridum 的效果我 到 ，电流在 HF 组有重要减少，与控制组相比。密度我 到在 HF 的 ，组在 allitridum 的处理以后被增加(30 ????????? 佐 ??? 啓位 ??? 潃据畬楳湯即偎？？

英文摘要：

Objective To study the effect of allitridum on the transient outward potassium current （Ito） of ventricular myocytes in heart failure （HF）. Methods The dual enzymatic method was used to separate single ventricular myocytes from Sprague Dawley rats. Patch-clamping was used to record Ito and analyze the effect of allitridum on the current. Results The Ito current had a significant decrease in the HF group, compared with the control group. The density of Ito in the HF group was increased after treatment of allitridum （30 μmol/L）. The peak current densities of Ito were enhanced in the HF group from 6.01 ±0.30 pA/pF to 8.41 ±0.54 pA/pF （P 〈 0.01） at ＋50 mV after treatment with allitridum （30 μmol/L）. We also determined the effect of allitridum on the gating mechanism of the Ito in the HF group. Conclusions We found that allitridum increased the Ito by accelerating the activation of channels and shortened the time constants of inactivation, and allitridum decreased the remodeling of Ito in ventricular myocytes of rats with HF.

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期刊信息
  • 《药学学报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学技术协会
  • 主办单位:中国药学会 中国药学科学院药物研究所
  • 主编：王晓良
  • 地址：北京市先农坛街1号
  • 邮编：100050
  • 邮箱：yxxb@imm.ac.cn
  • 电话：010-63026192
  • 国际标准刊号：ISSN：0513-4870
  • 国内统一刊号：ISSN：11-2163/R
  • 邮发代号:2-233
  • 获奖情况:
  • 国家期刊奖,国家“双高”期刊,2002年为第2届国家期刊奖百种重点科技期刊并获第3...
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  • 被引量:37721