中文摘要：

目的探讨血清中B细胞刺激因子（BAFF）和增殖诱导配体（APRIL）水平与原发性胆汁性肝硬化（PBC）的关系。方法选择PBC、慢性乙型肝炎（CHB）患者和健康献血者（HC）各12例，采用ELISA法检测血清中BAFF和APRIL的表达水平。结果PBC组血清BAFF水平明显高于CHB组（P=0．008）和HC组（P=0．012），但ARPIL水平在三组间差异无统计学意义。血清BAFF水平与谷草转氨酶呈正相关（r=0．391，P=0．020），与血清白蛋白呈负相关（r=-0．434，P=0．017）；血清APRIL水平与患者年龄呈正相关（r=0．551，P=0．002），与血清白蛋白呈负相关（r=-0．424，P=0．039）。结论PBC患者血清BAFF水平明显升高，并与肝脏损害程度相关。

英文摘要：

Objective To investigate the relationship between the serum levels of B-cell activation factor（BAFF） or a proliferation-inducing ligand （APRIL） and the disease severity of primary biliary cirrhosis （PBC）. Methods The clinical data were collected from 12 cases of PBC, chronic hepatitis B （CHB） , healthy control （HC） , respectively. The serum levels of BAFF and APRIL were assayed by ELISA. Results The serum levels of BAFF in patients with PBC were signifi- cantly higher than those in patients with CHB（ P = 0. 008） and HC controls （P = 0.012 ）. While there was no significant difference among the three groups on the profile of APRIL levels. There was a significant correlation between serum BAFF levels and AST （r =0.391 ,P =0.020） or ALB （r= -0.434, P=0.017）, and the APRIL levels correlated with ages （r = 0.551 ,P = 0.002） or ALB （r = - 0.424,P = 0.039）. Conclusions The serum levels of BAFF significantly elevate in patients whith PBC and associate with the severity of liver injury.