京尼平(Genipin)是具有环烯醚萜结构的化合物,具有抗血栓、降血糖、抗肿瘤、抗炎和抗老年痴呆等多种药理活性。近年来,人们通过对其结构进行修饰改造,获得了一系列具有抗阿尔兹海默病(AD)活性的京尼平衍生物。对京尼平及其衍生物抗阿尔兹海默病作用的研究进展进行综述,为京尼平的开发利用提供依据。
Genipin is an iridoid compound,and has shown anti-thrombus,antidiabetics,antitumor,anti-dementia,anti-inflammatory and other pharmacological activities.In recent years,people obtain a series of Genipin derivatives on anti-Alzheimer's disease activity by the structure modification.In this work,a review of Genipin and its derivatives on anti-Alzheimer' s disease activity has been provided.