中文摘要：

C 反应的蛋白质(CRP ) 是尖锐阶段反应物五个相同子单元填写了的一个 prototypic 人。新兴的证据显示 CRP 不仅仅是心血管的疾病的一个预言者，但是可以也是一个直接调停人。然而， CRP 的多样、有时矛盾的活动更加妨碍了尝试在 atherogenesis 定义 CRP 的准确角色。这里，我们考察 CRP 结构和功能的规定的多重层，加亮局部炎症怎么调节，例如许多损坏房间膜和氧化还原作用动态平衡，能付小费给支持 inflammatory 的平衡和 CRP 的反煽动性的活动。我们建议在 CRP 的不同结构的符合构造之间的高度控制的相互影响作为发炎和 atherogenesis 的一个好调节的人位于它的内在的性质下面。

英文摘要：

C-reactive protein （CRP） is a prototypic human acute phase reactant composed of five identical subunits. Emerging evidence in- dicates that CRP is not merely a predictor of cardiovascular disease, but may also be a direct mediator. However, the diverse and sometimes contradictory activities of CRP have considerably hampered the attempts to define the exact role of CRP in atherogen- esis. Here, we review the multiple layers of regulation of CRP＇s structure and function, highlighting how local inflammation con- ditions, such as the abundance of damaged cell membranes and redox homeostasis, can tip the balance of the pro- and anti- inflammatory activities of CRP. We propose that the highly controlled interplay between different structural conformations of CRP underlies its intrinsic property as a fine modulator of inflammation and atherogenesis.