第一次,在表面应力之间的连接和在 microcantilever 上吸附的 DNA 的 nanoscopic 相互作用被联合 Strey 的 mesoscopic 液体水晶理论和 Stoney 的公式建立。表面应力 DNA biofilm 的 biomolecular 相互作用取决于不仅而且在伸臂的机械性质上,这被显示出。就在 grafting 密度和 DNA 链的链长度之间的相互关系而言,我们讨论 DNA-microcantilever 系统和 DNA 答案系统之间的差别。这个模型的主要理论成就是在不同察觉条件下面识别主要贡献到表面应力。这为与高敏感和改进可靠性设计新生物传感器提供指南。
For the first time, the connection between surface stress and nanoscopic interac- tions of DNA adsorbed on microcantilever is established by combining Strey's mesoscopic liquid crystal theory and Stoney's formula. It is shown that surface stress depends not only on biomolec- ular interactions of DNA biofilm but also on mechanical properties of cantilever. Considering the correlativity between grafting density and chain length of DNA chain, we discuss the differences between DNA-microcantilever system and DNA solution system. The major theoretical achieve- ment of this model is to identify the main contributions to surface stress under different detection conditions. This provides guidelines for designing new biosensors with high sensitivity and improved reliability.