中文摘要：

目的观察腹腔注射川芎嗪对脑缺血—再灌注大鼠神经功能及神经电生理的影响。方法将20只大鼠随机分为A、B组，制作大鼠大脑中动脉栓塞模型后，分别腹腔注射生理盐水及川芎嗪80mg／kg，2次／d，连用7d。采用双盲法行大鼠神经功能评分，采用TTC染色法测量大鼠脑梗死灶体积，并行运动诱发电位检测。结果A组神经功能评分为（3．31±0．23）分，脑梗死灶体积为（45．63±12．75）mm^3，运动阈值为52．67％±8．75％，B组分别为（2．30±0．15）分、（26．59±7．64）mm^3、34．29％±5．18％，P均〈0．05。损伤后的运动阈值与脑梗死灶体积呈正相关（r=0．68，P〈0．05）。结论川芎嗪可减小缺血—再灌注损伤脑组织梗死灶体积，提高皮质兴奋性。

英文摘要：

Objective To observe the effects of ligustrazine on neurvous function and cortical excitability of rats with cerebral ischemia-reperfusion injury. Methods 50 Healthy male SD rats were randomly divided into 5 groups ： sham operation group, model group, low-dose lignstrazine group （20 mg/kg）, middle-dose ligustrazine group （40 mg/kg）, high-dose lignstrazine group （80 mg/kg）. All medications were given intraperitoneally twice a day for 7 days. Motor threshold （ MT）, motor evoked potential （MEP） and the scores of neurological deficits were evaluated. Results 7 days after MCAO reperfusion, the scores in middle and high-dose ligustrazine group were significantly lower than those of the model group. The infarct volumes of high-dose lignstrazine group were significantly smaller than those of the model group （ P 〈 0.05 ）. The post-injury MT of the model group was significantly higher than the preinjnry level. The post-injury MT of the high-dose lignstrazine group was significantly lower than that of the model group. Positive linear correlation was found between post-in- jury motor threshold and infarct volume. Latency of MEP in the model group and lignstrazine group was significantly prolonged compared with that of the previous. Compared with the pre-injury level, there was no significantly difference of the post-injury latency of MEP in model group and ligustrazine group （ P 〉 0.05 ）. Conclusion Ligustrazine can protect neuro effect on MACO reperfusion, reduce the infarct volumes, increase the cortex excitability.