中文摘要：

肿瘤细胞的恶性增殖依赖细胞内的高多胺水平，抑制多胺合成或促进多胺分解均能够降低肿瘤细胞内的多胺水平，因此通过耗竭肿瘤细胞中的多胺含量抑制肿瘤细胞增殖成为新的抗肿瘤研究策略。本文简要综述了近年来以多胺代谢为靶点，通过多种方式耗竭肿瘤细胞内多胺的抗肿瘤研究进展。

英文摘要：

Rapid tumor cell growth depends on intracellular polyamine levels higher than those of normal cells. Intracellular polyamine depletion inhibits tumor cell proliferation and induces tumor cell apoptosis. Therefore, polyamine metabolism has recently been identified as an important target for anti-tumor therapy. This article briefly summarizes recent polyamine metabolism targeting, polyamine depletion within the tumor cells through a variety of methods, and the antitumor effects of the treatment.