中文摘要：

为了比较研究不同极性不同表面电位的驻极体对模型药物5-氟尿嘧啶（5-Fu）经离体大鼠皮肤的渗透规律及其在大鼠皮肤内分布的影响,利用表面电位为±500 V、±1 000 V和±1 500 V的聚丙烯（PP）驻极体为促渗源,并与未经驻极体作用的对照组进行对比,利用萃取等提取分离技术将大鼠皮肤内部的模型药物5-Fu滞留量检测出来,研究了驻极体对5-Fu经离体大鼠皮肤的渗透规律及其在大鼠皮肤内分布的影响。结果显示：（1）-1 000 V和-1 500 V驻极体作用5-Fu 36 h时间,其累积透皮量均较对照组有显著增加（P〈0.05）,且负极性驻极体的表面电位绝对值越高,药物的累积透皮量就越大;（2）1 000 V和1 500 V驻极体作用5-Fu 36 h时间,5-Fu的累积透皮量均低于对照组,但在角质层和去角质层皮肤内的5-Fu滞留量显著增加（P〈0.05）,且随驻极体表面电位增高和时间的增加而增加。因此,合理选择驻极体的极性、表面电位和时间,有望给增生性瘢痕的治疗提供新方法和新剂型,同时也为皮肤肿瘤的治疗提供新思路。

英文摘要：

Adopting ±500 V, ±1 000 V, and ±1 500 V polypropylene（PP） electrets as physical strategy, we studied their enhancing effects on in vitro transdermal delivery of 5-fluorouracil（5-Fu） through rat skin and the residual amount of 5-Fu in stratum corneum（SC） and SC stripped rat skin.The results were compared with those of the control group in the absence of PP electret application. The results indicate that（1） the 36-hour cumulative penetration amount of 5-Fu through rat skin in vitro after application of-1 000 V and-1 500 V PP electrets are significantly increased（P〈0.05） with increasing effectively surface potential in absolute value.（2） On the other hand, the 36-hour cumulative penetration amount of 5-Fu after application of ＋1 000 V and ＋1 500 V PP electrets are significantly decreased（P〈0.05）. However, the residual amount of 5-Fu in SC and SC stripped skin are obviously increased（P〈0.05） with increasing effective surface potential and application time of the positive electrets. Therefore, the appropriate selection of electrets polarity, magnitude of surface potential, and application time may provide a new route for treatment of hypertrophic scar and skin tumors.