中文摘要：

为研究正极性聚丙烯驻极体对5-氟尿嘧啶（5-FU）压敏胶贴剂和含化学促渗剂（质量分数3％氮酮）5-FU压敏胶贴剂中药物体外释放的影响，采用常温电晕充电技术制备1000V和2000V驻极体，以压敏胶Eudragit E100为基质，柠檬酸三丁酯为增塑剂，水溶性氮酮为化学促渗剂，制备驻极体5-FU贴剂。借助于Franz扩散池和高效液相色谱仪检测贴剂的体外累积释放量。结果表明：1）正极性聚丙烯驻极体表面电位越高，外静电场越强，对5-FU压敏胶贴剂中药物释放的提高越多。2）1000V和2000V聚丙烯驻极体分别作用于含3％氮酮的5-FU贴剂36h，贴剂的药物释放量分别较5-Fu贴剂提高2．53倍和3．10倍。3）正极性聚丙烯驻极体通过改变5-FU贴剂的介电特性和降低贴剂黏滞力增加药物的释放。正极性聚丙烯驻极体与3％氮酮联用可进一步增加5-FU贴剂的药物释放量，从而给增生性瘢痕的治疗提供新剂型和新方法。

英文摘要：

To study the effects of positive polypropylene（PP） electrets on cumulative release amounts of 5-fluorouracil （5-FU） from 5-FU patch and chemical enhancer （3% azone） containing 5-FU patch, the ambient temperature corona charging technology was applied for preparation of 1 kV and 2 kV electret. For the preparation of 5-FU patch with electret, pressure-sensitive adhesive Eudragit E100 was used as matrix, tributyl citrate esters as plasticizer, and water-soluble azone as chemical permeation enhancer. The Franz diffusion pool and high performance liquid chromatograph were used to investigate the release rule of positive polarity electret electrostatic field to 5-FU in vitro. Results show that higher external electrostatic field of positive PP electrets with higher surface potential results in more drug release from 5-FU patches. The cumulative release amount of 5-FU from the 3% azone containing 5-FU patches at 36 h under the action of 1 kV and 2 kV PP electrets are 2.53 and 3.10 times as compared with that of the 5-FU patch, respectively. Positive PP electrets can increase the drug release from the patch by changing the dielectric property and viscose force of the patch. The combination of electrets and 3% azone can remarkably increase the release of 5-FU from its patches, which provides a new formulation and new strategy for treatment of hypertrophic scar.