中文摘要：

目的探讨慢肝纤维化、肝硬化肝脏体积变化规律及其与病理学分期的相关性。方法对经肝穿病理活检确诊的肝纤维化S1期8例、S2期11例、S3期7例、S4期／早期肝硬化10例、具有典型临床症状和影像学表现的中晚期肝硬化15例以及16例正常组行16层螺旋CT肝脏容积扫描，采用仪器自身携带的Volume功能软件，分别测量肝脏左外叶、方叶、右叶以及尾状叶的体积，计算全肝的体积以及各个肝叶占全肝的百分比，并与病理学分期作对照研究和统计学分析。结果正常肝脏的大小为（1097．12±103．53）cm^3，左外叶、方叶、右叶、尾状叶的大小及其占全肝的百分比依次分别为（166．53±22．05）cm^3、（190．45±18．54）cm^3、（714．96±43．22）cm^3、（25．18±4．02）cm^3；（15．13±1．07）％、（17．34±0．58）％、（65．25±1．48）％、（2．29±0．23）％。从S1期至肝硬化，肝左外叶体积逐渐增大。典型肝硬化左外叶容积及所占百分比明显增大，与其他各组比较均有显著性差异。重度肝纤维化S3、4期／早期肝硬化左外叶容积和／或其百分比与正常组比较有统计学差异（P〈0．05）。方叶体积在S1～S3期轻度增大，S4期／早期肝硬化、典型肝硬化则明显变小且组间比较均有统计学差异。除了典型肝硬化组右叶体积（502．67±112．44）cm^3及其百分比（55．20±8．72）％明显变小，与其他各组比较具有统计学差异，S2期肝右叶体积显著大于正常组（P〈0．01）外，余各组间右叶体积及所占百分比均无显著差异。肝硬化组尾状叶容积和／或其所占百分比与其他各组之间均存在着显著的统计学差异，余各组问均无差异。总肝体积先增大后缩小，典型肝硬化与其他各组比较均有统计学差异（P〈0．01），肝纤维化S1～4各期之间差异均无显著意义；S4期／早期肝硬化组总肝体积较S2、3期变?

英文摘要：

Objective To investigate the rule of hepatic volume change in chronic hepatic fibrosis and cirrhosis and the relativity with histopathologic stage. Methods A volume CT scan was performed in 67 participants, including 36 patients with hepatic fibrosis which included S1 （ 8/36 ）, S2 （ 11/36 ） ,S3 （ 7/36 ） and S4 （ 10/36 ） confirmed by liver pathologic biopsy, 15 patients with liver cirrhosis who had typical clinical and image signs, and 16 healthy subjects as control group. The volume of the left lateral lobe, medial lobe, right lobe and the caudate lobe were measured respectively,the total liver volume and percentage of each lobe in the liver were calculated in comparison with histopathologic stage . Results In control group , the total liver volume was （ 1097.12 ± 103.53 ） cm^3 ,the volume and the percentage in the total liver of the left lateral lobe , medial lobe, right lobe and the caudate lobe were （ 166.53 ± 22.05 ） cm^3 , （ 190.45 ± 18.54 ） cm^3 , （714.96±43.22） cm^3,（25.18±4.02） cm^3 and （15.13 ±1.07）%,（17.34±0.58）%,（65.25 ±1.48）%,（2.29 ±0.23）%,respectively. From S1 to liver cirrhosis, the left lateral lobe enlarged gradually. The volume and percentage of the left lateral lobe in patients with typical cirrhosis increased markedly and had significant difference with other groups . The volume and/or percentage of the left lateral lobe between S3,4/early stage of hepatic cirrhosis and the normal liver were of statistically difference . The quadrate lobe enlarged slightly （ S1 ～S3 ） but reduced markedly at S4 and liver cirrhosis and had prominent statistical difference between groups . Except typical cirrhosis , the volume and percentage of the right lobe and the caudate lobe had no significant difference among groups of S1 ～ S4. The total liver volume increased in patients with fibrosis but decreased in typical cirrhosis , there was dramatic statistical difference between liver cirrhosis and other groups , but the differences among groups of