目的:研究消定膏对家兔完整皮肤的刺激性及其对皮肤的致敏性。方法:家兔去毛后左侧区域为空白对照区,涂以蒸馏水0.5 mL;右侧区域为给药区,涂以0.5 g消定膏,每天涂抹1次,连续7 d,观察及记录红斑及水肿等情况,并按皮肤刺激反应评分标准进行评分研究其对完整皮肤的刺激性;通过与高致敏物2、4-二硝基氯苯比较研究其致敏性。结果:在连续贴敷消定膏第4天和第5天开始出现轻度红斑,贴敷第5天开始出现轻度水肿,停药后48 h逐渐恢复,对皮肤无过敏反应;消定膏过敏发生率为0%,无皮肤过敏反应。结论:消定膏对家兔完整皮肤具轻度刺激性,对皮肤无致敏反应。
Objective: To study skin irritation and sensitization of Xiaoding Gao with rabbit. Methods: After removing rabbit hair, the left side is blank controlled area, coated with distilled water 0. 5 mL; The right is medicine area and coated with 0. 5 g Xiaoding Gao, once daily, continuous 7 d, observe and record erythema, edema indicators, rate according to the 'skin stimulation reactions rating criteria'. Skin sensitization of 2,4-two nitro chlorobenzene, which is highly allergic. was appeared at 4th or 5th day, mild edema was found Xiaoding Gao is compared with Results: After continuous applying Xiaoding Gao, mild erythema at 5th day. 48 h after discontinuation of Xiaoding Gao, erythema and edema disappeared gradually, and there wae no skin allergic reaction. The allergic rate of Xiaoding Gao is 0%. Conclusion: Xiaoding Gao has little skin irritation and no sensitization effect to complete rabbit skin.