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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

ISSN号：1671-4695
期刊名称：《临床和实验医学杂志》
时间：0
分类：S816.7[农业科学—饲料科学;农业科学—畜牧学;农业科学—畜牧兽医] S858.292[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：[1]Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou 515031, China, [2]Cancer Research Center, Shantou University Medical College, Shantou 515031, China, [3]The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515031, China, [4]Department of Pathology, Shantou University Medical College, Shantou 515031, China
相关基金：This study is partly supported by the National Basic Research Program of China （973 Program, Grant No. 2011CB707705）, the National Natural Science Foundation of China （Grant Nos. 31271068 and 81302331）, and Guangdong Provincial Key Laboratory on Breast Cancer Diagnosis and Treatment Research.

作者： Xiaolong Wei[1], Chunfa Chen[2,3], Didi Xi[2,3], Jinwen Bai[2,3], Wenhe Huang[3], Luoxiang Rong[2,3], Mingyao Wu[4], Guojun Zhang[2,3]

关键词：神经内分泌, 乳腺癌, 原发性, 化疗, 生物标记物, 检测诊断, 免疫组化, 病理诊断, neuroendocrine carcinoma, neo-adjuvant therapy, breast

中文摘要：

主要 neuroendocrine 胸癌(NEBC ) 是乳癌的一种很稀罕的类型。二典型 biomarkers，也就是 CgA 和 Syn，应该 immunohistochemically 被检测诊断 NEBC。在这研究，有 8.3 厘米椠瑮獥楴慮? 的一个大团的一个 43 岁的女人 ? 呓 ? 桴 ? 潮敶 ? 獵? 景琠牡敧整 ? 桴牥灡 ? 湡 ? 条牧獥楳敶猠牵楧慣? 牴慥浴湥 ? 牰摯 ' 讚瓲剳 V 潳慮汢? 潧摯猠牵楶慶? 畯 ' 咒矗?

英文摘要：

Primary neuroendocrine breast carcinoma （NEBC） is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy （partial response based on RECIST criteria） and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.

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