中文摘要：

目的：检测乳腺癌中CD146的表达情况以及分析与临床病理特征的相关性。方法：收集10例正常乳腺和79例乳腺癌组织标本;用免疫组化法检测CD146、ER、PR、HER2、P53的表达,分析CD146表达与乳腺癌临床病理特征的相关性。结果：CD146在正常乳腺组织中不表达,在乳腺癌中的表达率约24.1%,且组织学级别越高,其表达率越高（P〈0.05）;CD146表达的乳腺癌中,ER、PR多为阴性表达（P〈0.05）;CD146的表达与年龄、肿瘤大小、淋巴结转移情况、以及与HER2和P53的表达无关。结论：CD146在ER阴性表达的乳腺癌中高表达,可能与肿瘤上皮间质转化有关。

英文摘要：

Objective： To detect the expression of CD146 in breast cancer, and to analyze the relationship between its expression and breast cancer clinicopathological features. Methods： Tissue samples of 10 normal breast and 79 breast cancer were collected. The expressions of CD146, ER, PR, HER2 and P53 were detected by immunohistochemistry. The relationship between CD146 expression and the clinicopathological features of breast cancer was analyzed. Results： CD146 was not expressed in normal breast tissues, but was expressed in about 24.1% of breast cancers tissues, with an intently of higher expression in breast cancers with higher histological grade （P〈0.05）. CD146 was predominately expressed in ER and PR negative breast cancer （P〈0.05）. CD146 expression was not related to age, tumor size, lymph node metastasis, as well as to HER2 and P53 expression. Conclusion： CD146 is highly expressed in ER negative breast cancer and may be involve in epithelial-mesenchymal transition in breast cancer.