中文摘要：

采用无溶剂无催化剂合成方法，分别进行了以O，O′-二烷基亚磷酸酯、3，4，5-三甲氧基苯甲醛、2．氨基取代苯并噻唑为原料的类Mannich一锅法合成反应研究，经合成筛选，优选出控制反应温度100℃，无溶剂、无催化剂加热反应120min的合成方法，实验结果表明该方法经济、简便、对环境友好．经元素分析，IR，^1H NMR，^13C NMR对所合成的化合物进行了结构确认和表征．培养并测定了化合物钿的晶体结构．初步生物活性测试表明，化合物具有一定的抗烟草花叶病毒活性.

英文摘要：

The Mannich-type addition of O,O＇-dialkyphosphite to 3,4,5-trimethoxybenzaldehyde and 2-aminobenzothiazole was carried out in one pot by means of adopting solvent-catalyst free condition. The optimized condition is at 100 ℃ and 120 rain without catalyst and solvent, which is economic, convenient, high yields and environment-friendly. Their structures were clearly established by elemental analysis, IR, ^1H NMR and ^13C NMR spectra. Single crystals of 4a have been obtained and determined. The bioassay of some compounds showed that they have moderate anti-tobacco mosaic virus （TMV） activity.