中文摘要：

半乳凝集素3是一类能选择性识别糖结构并与之非共价结合的蛋白质,心房纤颤的危险因素可以有效的促进从巨噬细胞释放半乳凝集素3,而半乳凝集素3通过参与调节成纤维细胞的激活和增殖,最终导致心脏纤维化、心脏重构、心脏功能障碍,最终诱发及维持心房纤颤。

英文摘要：

Galectin-3 belongs to a family of β-galactoside-binding proteins,which is characterized by highly conserved sequences in specific carbohydrate-recognition domains. A number of conventional risk factors for atrial fibrillation may be effective to promote the release of galectin-3 from macrophages,which in turn contributes to increasing accumulation of inflammatory cells in cardiac tissue and perpetuates their activation,promotes fibroblast activation and proliferation,thus leading to cardiac fibrosis,cardiac remodeling,myocardiocyte dysfunction and ultimately predisposing to atrial fibrillation.