中文摘要：

目的：探讨氟骨症患者血清中骨钙素（Osteocalcin，OCN）与糖代谢之间的关系。方法：在新疆阿克苏地区饮水型氟中毒病区沙雅县等，通过WS192-2008《地方性氟骨症诊断标准》确诊的患者60例作为氟骨症组；选取该地区经相同诊断方法诊断为无氟中毒骨病变的，且经X线拍片排除佝偻病等相关骨骼疾病的健康60例作为对照组。采集血清酶联免疫吸附实验（Enzyme-linkedimmunosorbent assay，ELISA）法与化学法等检测总骨钙素（Total osteocalcintOCN）、未羧化骨钙素（Uncarboxylated osteocalcin，ucOCN）、空腹胰岛素（Fasting insulin，FINS）、空腹血糖（Fasting blood glucose，GLU）72．糖化血清蛋（Glycated serum protein，GSP）水平，计算胰岛素抵抗指数（Insulin resistance index，HOMA-IR）。SPSS16．0软件进行数据统计，Pearson法分析氟骨症OCN与糖代谢指标之间的相关性。结果：与对照组比较，氟骨症组ucOC、FINS、GSP水平显著升高（P〈0．05）。氟骨症组OCN、HOMA-IR较对照升高但无统计学差异（P〉0．05）。氟骨症组GLU水平与对照组相比降低但无统计学差异（P〉0．05）。相关回归分析显示氟骨症组ucOC与FINS呈正相关（r=0．543，P〈0．05），与GLU、HOMA-IR呈负相关性（r=-0．902，r=-0．530，P〈0．05），与OCN、GSP无相关性（P〉0．05）。结论：氟骨症患者血清未羧化骨钙素显著升高，影响胰岛素分泌与抵抗，与糖代谢紊乱有一定相关性。

英文摘要：

Objective： To investigate the relationship between serum osteocalcin （OCN） and glucose metabolism in patients with skeletal fluorosis. Methods： Sixty patients were diagnosed as skeletal fluorosis by WS192-2008 ＂Diagnostic criteria of endemic skeletal fluorosis＂ in shaya county, Aksu area in xinjiang, where is drinking water type fluorosis ward. Sixty healthy people were regarded as control groups using the same method, which excluded rickets by x ray. The serum levels of Total osteocalcin （tOCN）, Uncarboxylated osteocalcin （ucOCN） and Fasting insulin （FINS） were detected by enzyme-linked immunosorbent assay （ELISA） and the serum levels of Fasting blood glucose （GLU） and Glycated serum protein （GSP） were analyzed by chemical method, then calculated the insulin resistance index （HOMA-IR）. SPSS16.0 software was used to data statistics, and the correlation between OCN and glucose metabolism was analyzed by Pearson method. Results： Compared with the control group, the levels of ucOCN, FINS and GSP in the skeletal fluorosis group were significantly increased （P 〈0.05）, OCN and HOMA-IR in the skeletal fluorosis group increased, but no statistical difference （P〉 0.05）.GLU level in the skeletal fluorosis group decreased but was no significant difference between the skeletal fluorosis group and the control group （P〉 0.05）. Correlative regression analysis showed that ucOCN was positively correlated with FINS in skeletal fluorosis group （r --0.543, P〈0.05）, UcOCN was negatively correlated with GLU and HOMA-IR in skeletal fluorosis group, （r =-0.902, r =- 0.530, P〈0.05）, UcOCN was no correlation between with OCN and GSP in skeletal fluorosis group （P〉 0.05）. Conclusion（s）： The serum level of ucOCN was significantly elevated in patients with skeletal fluorosis, possibly affecting insulin secretion and resistance, and having a certain relevance with glucose metabolism disorders.