中文摘要：

目的通过研究社会互作奖赏剥夺对小鼠代谢性学习记忆的影响,为进一步探讨亲子关系、社会隔离、集体生活等社会互作活动与儿童摄食行为之间的关系提供理论基础和实验依据。方法共39只3月龄的雄性C57BL/6J小鼠随机分为群居组和独居组,然后分别进行能量偶联的条件性口味偏好训练。由于小鼠在建立口味偏好的训练过程中,为单只在单个饲养笼中进行,所以群居组小鼠的训练就模拟了社会互作奖赏剥夺,长期未体验社会互作奖赏效应（也不存在社会互作奖赏剥夺）的独居组为对照组。结果在未进行条件性口味偏好训练的前期选择测试过程中,社会互作奖赏剥夺组小鼠对仅具口味（尚无能量的意义）的溶液摄取量明显少于对照组小鼠（P〈0.001）,但对两种不同仅具口味的溶液摄取量无明显差别（P〉0.05）;以代谢性能量作为非条件刺激进行口味偏好训练后,社会互作奖赏剥夺小鼠和对照组小鼠都对能量偶联的口味溶液形成显著的偏好性（P〈0.001）,但是社会互作奖赏剥夺小鼠的能量偏好程度显著低于对照组小鼠（P〈0.001）。整个训练过程中,小鼠的体重并无明显改变。结论社会互作奖赏剥夺显著影响小鼠的摄食行为,尤其对小鼠的代谢性的口味学习记忆造成显著影响。该研究提示,社会互作奖赏对于儿童正确摄食行为习惯的建立具有十分重要的作用。

英文摘要：

Objective To research the effects of social withdrawal on the metabolic learning and memory,to shed more lights on the relationship between social activities such as parent-child relationship,social isolation,collective life and feeding behaviors in children. Methods A total of 39three-month-old male C57BL/6Jmice were randomly divided into communally and lonely living groups,both of which were then subject to the conditioned flavor preference training using the metabolic energy as the unconditioned stimulus.As the feeding training was done in a single-living behavioral cage,where the communally but not lonely living mice would produce strong social withdrawal.The effects of social withdrawal on the metabolic learning and memory were assessed. Results Prior to conditioned flavor preference training,the social withdrawal group of mice drunk less flavored solution during the pre-test period compared with the control group,but had no significant preference over the two unconditioned flavors.After the conditioning,both groups of mice preferred to the flavor coupled with energy metabolism over the other one.However,the social withdrawal group of mice produced less flavor preference compared with control.During the entire training process,there were no significant changes in body weight of both groups of mice. Conclusion Social withdrawal indeed significantly affects feeding behavior,especially on the metabolic learning and memory in mice.The research emphasizes on the impact of proper social interaction for diet feeding behavior in children.