中文摘要：

帕金森病（Parkinson＇s disease,PD）的特异标志物Alpha-突触核蛋白的异常聚集往往伴有铁的沉积,说明铁与Alpha-突触核蛋白聚集之间存在一定联系。铁可以通过增加Alpha-突触核蛋白的产生及抑制其降解从而促进Alpha-突触核蛋白聚集。Alpha-突触核蛋白作为一种高铁还原酶也可以影响细胞铁的代谢。本文就铁与Alpha-突触核蛋白参与PD的发病以及两者之间相互作用的机制进行综述。

英文摘要：

Both iron and alpha-synuclein accumulation are one of hallmarks of Parkinson ＇s disease（ PD）. Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron,indicating that there is a certain link between iron and alpha-synuclein aggregation. Iron promotes alpha-synuclein aggregation by increasing its synthesis and decreasing its degradation. Also,alpha-synuclein regulates iron metabolism through its ferrireductase activity. In this review,we will describe the roles of iron and alpha-synuclein in PD pathogenesis,and the mechanisms of iron and alpha-synuclein interaction.