中文摘要：

雌激素是一种类固醇激素，主要由卵巢产生，通过与受体结合来发挥其生物学效应并对机体代谢产生影响。研究者发现在动物体内雌激素水平的变化同时也伴随着机体内铁的储量的变化。近几年雌激素反应元件（estrogen response element, ERE）的发现提示雌激素能够直接参与哺乳动物铁代谢的调节。本文就雌激素参与机体各个系统铁代谢的调节及相关机制做了综述，以期为雌激素的临床用药提供指导。雌激素与铁代谢关系密切，其具体调节机制还有待进一步深入探讨。

英文摘要：

Estrogen is a steroid hormone produced mainly by the ovaries. It combines with the nuclear receptors to exert the biological effects influencing the metabolism of body. Elevated levels of estrogen are often associated with altered iron levels in mammals. Fur- thermore, the findings of estrogen response element （ERE） have demonstrated that estrogen affects iron metabolism directly in periph- eral tissues. In this review, we will briefly summarize the effect of estrogen on iron metabolism in mammals, and discuss recent prog- ress in the mechanisms of estrogen on some iron related proteins in order to provide guidance for clinical use of estrogen. Estrogen and iron metabolism are closely related, but the exact regulatory mechanisms still need further exploration.