中文摘要：

目的研究内源性一氧化氮（NO）对麻醉SD大鼠肺循环阻力的影响。方法麻醉大鼠应用非选择性一氧化氮合酶（NOS）抑制剂N-硝基精氨酸甲酯（L-NAME）,分别实时监测系统动脉压（Psa）、肺动脉压（Ppa）、左心房压（Pla）、主动脉血流量（ABF）和气道压力（Paw）,观察大鼠肺循环阻力（PVR）的变化。结果麻醉大鼠应用L-NAME（10mg/kg）后,Psa迅速升高,ABF随Psa升高而降低,而Ppa、Pla和Paw没有出现明显变化,PVR受ABF降低的影响逐渐升高,给L-NAME 10 min后,PVR从基础值的（0.34±0.05）mmHg·min/mL升高到了（0.52±0.05）mmHg·min/mL,差异有显著性（P〈0.05）。结论内源性产生的NO没有参与肺动脉血管舒张度的调节。

英文摘要：

Objective To explore the effect of pulmonary vascular resistance to endogenous nitric oxide （NO） in anesthetized rats. Methods The nonselective nitric oxide synthase （ NOS ） inhibitor NG - nitro - L - arginine methyl ester L- NAME）was determined in anesthetized rats. Systemic arterial pressure （Psa）, pulmonary arterial pressure （ Ppa）, left atrial pressure （ Pla）, airway pressure （ Paw ）, and aortic blood flow （ABF） were directly and simultane- ously measured. To observed changes in pulmonary vascular resistance （PVR） of rats. Results In the rats treated with L -NAME（10mg/kg） ,the rats showed a decrease in ABF along with an increase in Psa quickly. PVR increased a- long with decreased in ABF. But Ppa, Pla and Paw did not change. At 10 min after L - NAME injection, PVR in- creased from（0.34 ± 0.05 ） mmHg· min/mL to （0.52 ± 0.05 ） mmHg produced NO did not involve in the regulation of pulmonary vascular in · min/mL. Conclusion The endogenously anesthetized rats.