中文摘要：

目的 探讨体素内不相干运动（IVIM）的DWI定量参数诊断兔非酒精性脂肪肝病的可行性。方法 采用49只新西兰大白兔,正常组采用标准饮食,实验组采用高脂高胆固醇饮食。采用10个b值的IVIM-DWI对实验兔肝脏成像,得到ADC值、扩散系数（D）、假扩散系数（D＊）和灌注分数（f值）。对各实验组间参数行单因素方差分析及两两比较。结果 最后实验样本为41只实验兔,正常组9只,Borderline组（可疑NASH组）13只,NASH组19只。NASH组、Borderline组的D、D＊、f及ADC值均低于正常组（P均〈0.05）;NASH组的D及ADC值低于Borderline组（P均〈0.05）,而两组D＊和f值差异无统计学意义（P均〉0.05）。结论 IVIM参数能客观反映兔非酒精性脂肪肝病的组织学改变,可作为非酒精性脂肪肝病的重要无创性量化评价指标。

英文摘要：

Objective To assess the feasibility of intravoxel incoherent motion-DWI （IVIM-DWI） in diagnosis of nonalco- holic fatty liver disease （NAFLD）. Methods Totally 49 healthy New Zealand rabbits were randomly divided into control group that were fed with standard diet, and HFD group that were fed with high fat and high cholesterol diet. IVIM-DWI using 10 b values were performed on all the rabbits. ADC, diffusion coefficient （D）, pseudo diffusion coefficient （D＂ ） and perfusion fraction （f） were measured respectively. One way ANOVA and multiple comparison were performed. Results Final cohort consisted of 41 rabbits, and 9, 13, 19 rabbits were grouped into control group, borderline （suspected NASH） group and NASH group, respectively. D, D＋ , f and ADC in borderline group and NASH group were lower than those in control group （all P〈0.05）. D and ADC in NASH group were lower than that in Borderline group （P〈0.05）. No signifi- cant difference were found of D＋ and f between Borderline and NASH group （P〉0.05）. Conclusion IVIM parameters can represent the histopathological changes of NAFLD quantitatively of rabbits and serve as a imaging biomarker for the nonin- vasive and quantitative evaluation of NAFLD.