中文摘要：

采用二次插层法成功制备了10-羟基喜树碱（HCPT）-癸二酸（SC）插层的层状双金属氢氧化物（LDH）.先采用共沉淀法制备SC柱撑LDH杂化物（SC-LDH）,再在乙醇介质中将HCPT插入LDH层间形成HCPT-SC-LDH纳米杂化物.依据SC和HCPT的分子尺寸和纳米杂化物的通道高度,推测SC分子在层间可能为双层排列,SC分子两端的羧基同时键合在同一个LDH层片表面上;HCPT分子插入（或溶入）SC分子碳氢链形成的疏水区中.所制备的纳米杂化物既可稳定HCPT的内酯环,又可明显提高HCPT的溶解度,还具有明显的药物缓释效果,其释放动力学过程符合准二级动力学方程.

英文摘要：

The nanohybrid of 10-hydroxyl eamptothecin （HCPT）-sebaeate （SC）-intercalated layered double hydroxide（ LDH）, HCPT-SC-LDH, was prepared by a secondary intercalation method. First, the nanohybrid of SC intercalated MgEA1-NO3 LDH was prepared by a co-precipitation method; second, HCFr was intercala- ted into the LDH＇ s gallery in ethanol medium. According to the gallery height of the SC-LDH sample and the size of SC molecule, a probably morphology of the SC molecules in the gallery of LDH was suggested that the SC molecules arranged as a bilayer structure in which two carboxylate groups of SC molecule combined onto one LDH layer surface. And HCPT was intercalated into the LDH＇ s gallery via hydrophobic interaction. The encapsulated HCPT could keep biologically active lactone structure, and the nanohybrid could improve the HCPT solubility. Moreover, the obtained HCPT-SC-LDH nanocomposites showed obvious controlled release and the release in vitro of HCPT could be fitted with the pseudo-second-order model.