中文摘要：

以Triton X-100六角相溶致液晶作微反应器,采用共沉淀法制备了镁铝层状双金属氢氧化物（LDHs）纳米薄片（L-LDHs）.以双氯芬酸钠（DS）为药物模型分子,采用离子交换法制备了DS插层LDHs（DS/L-LDHs）纳米杂化物,在37.0°C、p H=7.2的缓冲溶液中,考察了纳米杂化物的药物释放性能,并与传统溶液共沉淀法制备的镁铝LDHs（S-LDHs）纳米片状颗粒进行了对比.采用粉末X射线衍射（XRD）、傅里叶变换红外（FT-IR）光谱、场发射扫描电镜（FE-SEM）、透射电镜（TEM）和N2吸附-脱附等技术对所制备的LDHs和DS/LDHs样品的晶体结构、比表面积、形貌特征等进行了表征.结果表明,L-LDHs比S-LDHs具有更低的片厚度,更高的比表面积和药物负载量,所形成的DS/L-LDHs纳米杂化物药物释放速率也明显低于DS/S-LSHs,即L-LDHs更适于作药物载体.DS/L-LDHs纳米杂化物的药物释放过程符合准二级动力学方程,受颗粒内部扩散过程控制.溶致液晶模板法可实现LDHs的形貌可控制备,为LDHs基功能材料的研发提供了新途径.

英文摘要：

A hexagonal lyotropic liquid crystal （LLC） was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide （LDH） nanosheets （L-LDHs） were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium （DS; DS/L-LDHs） was synthesized using an ion- exchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 ℃ and pH 7.2. The results were compared with those for common LDH flaky particles （S-LDHs） synthesized using a traditional solution coprecipitation method. The crystalline structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction （XRD）, Fourier-transform infrared （FT-IR） spectroscopy, field-emission scanning electron microscopy （FE-SEM）, transmission electron microscopy （TEM）, and N2 adsorption-desorption. The results show that the L-LDH particles are less thick, and have larger specific surface areas and higher DS-Ioading capacities than the S-LDH particles. Drug release by the DS/L-LDH nanohybrid was clearly lower than that by the DS/S-LDH nanohybrid. This indicates that the L-LDH nanosheets are more suitable for use as drug carriers than the S-LDHs. Drug release by the DS/L-LDH nanohybrid can be described using a pesudo-second-order kinetic model, and drug diffusion through the LDH particles is the rate-limiting step. LLC can be used as a template for morphology- controlled synthesis of LDHs.