中文摘要：

目的探讨左金丸及其类方对胃热证动物胃黏膜损伤的影响。方法采用辣椒汁加白酒灌胃2周,最后3d夹尾激怒引发热证模型。以不同比例黄连与吴茱萸配伍的验方左金丸、反左金丸、甘露散和茱萸丸灌胃给药治疗,代谢笼观察大鼠体温、食量、饮水量、大小便形状,同时检测血浆中白介素-8、白介素-2、肿瘤坏死因子α、血栓素B2和6-酮-前列腺素F1α含量及胃的组织学变化。结果在胃热证动物模型上,左金丸及其类方可不同程度改变大鼠血中白介素-8、白介素-2、肿瘤坏死因子α、血栓素B2和6-酮-前列腺素F1α水平。光镜和肉眼观察可见左金丸及类方均可改善黏膜损伤状况,其中以左金丸抑制损伤效果最好。结论不同比例黄连与吴茱萸经典验方可有效改善大鼠胃热证的各种症状和病理损伤,疗效因配比后药物寒热药性改变而有所不同。

英文摘要：

Objective To explore the difference effects of Zuojin Pills and its similar formulae on hot-syndrome gastric mucosal lesion and expression of correlative factors expression in rats. Methods The rat gastric hot model was established by oral administration with red pepper and alcohol mixture for two weeks and irritated for three days by clipping tails. Zuojin pill, Retro-zuojin pill, Zhuyus pill and Ganlusan were fed.The temperature, urine, feces, food and water consumption of every rat were detected with the help of the metabolism cage. The content of interleukin-8,interleukin-2,tumor necrosis facter-α,thromboxane B2 and 6-keto-prostaglandin-αin the blood of rats was examined. Meanwhile, the injury extent of gastric mucosa and the histological characteristics of gastric mucosa were observed. Results Zuojin and its similar formulae could change the level of IL-8,IL-2,TNFα,TXB2 and 6-keto-PGF1α in rat blood to different extents. Microscopic and macroscopic observation showed that the mucosa injury could be ameliorated by Zuojin pills and its similar formulae while Zuojin had the best effect on gastric mucosa injury inhibition. Conclusion The therapeutic effect of Zuojin and its similar formulae varies with the change in the cold and heat property of the formulae on the hot-syndrome gastric mucosal model.