中文摘要：

目的：研究黄连和吴茱萸不同比例组成的成药在胃肠道的溶出规律。即左金丸（6：1）,甘露散（2：1）,茱萸丸（1：1）和反左金丸（1：6）。方法：采用浆法,以pH=1.2的盐酸溶液作为溶出介质,利用超高效液相色谱法（ultra high per-formance liquid chromatography）,测定左金丸、甘露散、茱萸丸、反左金丸中的主要活性成分小檗碱、巴马汀、药根碱在3 h内的溶出量以及不同时间点的溶出速度。结果：类方中3种生物碱在3 h内的溶出量差异显著,随着黄连比例的减少,3种生物碱的溶出量依次降低,但并没有成相同比例的减少;溶出速度差异较小,都在5 min内达到最大溶出。结论：从体外溶出角度,左金丸及类方中的吴茱萸影响了黄连生物碱的溶出。

英文摘要：

AIM：To study the dissolution of the various weight ratio of coptis to evodia fruit,including Zuojin Pill（6 ： 1）,Ganlu Powder（2 ： 1）,Zhuyu Pill（1 ： 1） and Fanzuojin Pill（1 ： 6）,calculated as 30 gram/unit,in the gastrointestinal tract.METHODS：Paddle method was used,with hydrochloric acid（pH 1.2） as solvents,the cumulative contents of berberine,palmatine and jatrorrhizin in above pills and powder were determined with ul-tra high performance liquid chromatography in 3 h and the dissolution rates at measurement intevals.RESULTS：The dissolution amount of three alkaloids in the above pills and powder was obviously different,along with the de-crease in the weight ratio of Rhizome Coptidis,in the descenting order,berberine,palmatine and jatrorrhizin,but there was no significant difference in the dissolution velocity,and reached maximum dissolution rate in 5 min.CONCLUSION：From the viewpoint of in vitro dissolution,evodia fruit in Zuojin Pill and its similar prescription may interfere with the dissolution of alkaloids from coptis.