[^18F]氟代脱氧葡萄糖-正电子断层成像(^18F fluorodeoxyglueose-positron emission tomography,FDG-PET)能够反映出人体病变和正常组织的生理功能代谢变化,在肺癌的临床管理中具有重要的应用价值,在肺癌的诊断、分期、放疗计划的目标体积勾画、疗效监测、复发检查等方面都已得到越来越多的应用;但肺部炎症经常造成结果的假阳性,降低其诊断特异度。目前其分析手段包括基于静态图像的视觉分析、半定量化分析以及基于动态图像的定量分析。将介绍FDG-PET在肺癌管理中的应用现状、存在问题及未来研究方向。
FDG-PET has played a significant role in the clinical management of lung cancer since it can efficiently visualize the functional metabolic changes of normal and pathological tissues in human body. It has been used more and more widely in many aspects of lung cancer management including diagnosis, staging, target volume delineation for radiotherapy plan, treatment response inspection, and recurrence detection. However, the false positive ted by benign and inflammation somehow decreases its diagnostic specificity of lung cancer. The di-agnostic methods for lung cancer consist of visual interpretation and semi-quantitative analysis based on static imaging and quantitative analysis based on dynamic imaging. This article briefly reviews the current trends, challenges and foreground of this imaging modality in the field of clinical management of lung cancer.