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中文摘要：
目的对^18F氟代脱氧葡萄糖（^18F 2-fluoro-2-deoxy-D-glucose，FDG）在体内的代谢分布过程进行比较完整的全身模拟，并将这一模拟结果用高分辨率的三维可视化方法直观显示出来。方法通过临床实验估算出人体内多个组织的FDG代谢模型的参数，利用这些参数和血液输入函数模拟出FDG在人体组织内的代谢分布曲线，并基于高分辨率的解剖图像数据将这一代谢分布过程进行可视化。结果模拟和可视化的结果直观、清晰地反映了FDG注射到人体以后在体内进行代谢分布的过程，模拟结果所反映出来的分布变化特性与实际临床实验所给出的特性一致。结论本文给出了一种模拟人体代谢功能信息的有效方法，可以为临床核医学成像相关的教育和研究工作提供有用的工具。
英文摘要：
Objective To simulate the metabolic distribution process of ^18F 2-fluoro-2-deoxy-D-glucose （FDG） in human body and to visualize this distribution process through 3D images with high resolution and high quality. Methods The model parameters of FDG metabolism in tissues were estimated through clinical experiments, and.the curves which represent the FDG metabolic process in tissues were calculated using the model parameters and blood input function. This FDG distribution process in human body was visualized basing on the high-resolution anatomical structure. Results The simulation and visualization results directly and clearly displayed the FDG metabolic distribution process after injection to human body. The properties of the FDG distribution process represented by our simulation were consistent with that represented by clinical experiment. Condusion The method presented in this study is effective to simulate and visualize human functional information of metabolism, and it may provide a useful tool for education and research on nuclear imaging.
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