中文摘要：

目的探讨不同剂量T-2毒素在不同时间对大鼠氧化抗氧化能力的影响。方法将128只Wistar大鼠随机分为正常对照组、T-2毒素A组、T-2毒素B组、T-2毒素C组,分别喂成品颗粒饲料和经T-2毒素染毒（剂量分别为100 ng/g、200 ng/g、300 ng/g）的颗粒饲料。于实验3、6个月分批进行大鼠血清总抗氧化能力（T-AOC）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）、丙二醛（MDA）的检测。结果实验3个月,T-AOC水平,B组和C组降低（P均〈0.05）;GSH-Px活性,A组升高（P〈0.05）,C组降低（P〈0.05）;SOD活性,B组和C组升高（P均〈0.05）;MDA含量,C组降低（P〈0.05）。实验6个月,T-AOC水平,A组和B组降低（P均〈0.05）;各染毒组GSH-Px活性与对照组相比,差异无统计学意义;SOD活性,B组降低（P〈0.05）;MDA含量,C组降低（P〈0.05）。不同时间点比较,随着实验时间的延长,B组T-AOC水平明显下降（P〈0.05）;A组GSH-Px活性明显下降（P〈0.05）;对照组、A组和C组SOD活性均明显升高（P均〈0.01）;各组MDA含量均明显降低（P均〈0.01）。结论 T-2毒素可致机体氧化抗氧化指标发生改变,以总抗氧化能力的改变最为明显,不同剂量T-2毒素对机体产生的影响不同,随着时间的延长,T-2毒素对机体氧化抗氧化系统的损伤有加重的趋势。

英文摘要：

Objective To investigate the effect of different doses of T-2 toxin at different time on oxidative/antioxidative of rats.Methods 128 Wistar rats were divided into four groups randomly,which was control group,T-2 toxin A group,T-2 toxin B group,T-2 toxin C group.The rats were fed on commercial grain fodder and grain fodder contaminated with T-2 toxin（100 ng/g,200 ng/g,300 ng/g） respectively.At the end of 3,6 month,the oxidation/antioxidation index were detected,which were total antioxidant capacity（T-AOC）,glutathione peroxidase（GSH-Px）,superoxide dismutase（SOD）,malondialdehyde（MDA） in rat serum.Results In 3 month,the T-AOC levels in B and C group decreased（both P0.05）,the GSH-Px level in A group increased（P0.05）,while that in C group decreased（P0.05）,the SOD levels in B and C group increased（P0.05）,the MDA level in C group decreased（P0.05）.In 6 month,the T-AOC levels in A and B group decreased（both P0.05）,the GSH-Px levels in the T-2 toxin groups were no significantly different compared with the control.The SOD level in B group decreased（P0.05）,the MDA level in C group decreased（P0.05）.With the advancement of experiment,the T-AOC level in B group decreased markedly（P0.05）,the GSH-Px level in A group decreased markedly（P0.05）,the SOD levels in control group,T-2 toxin A and C group increased markedly（all P0.01）,the MDA levels in four groups decreased markedly（all P0.01）.Conclusions The oxidation/antioxidation indexes were affected by T-2 toxin.The T-AOC was the most obvious.The effect of different doses of T-2 toxin was different.With the advancement of the experiment,the oxidative damage induced by T-2 toxin was aggravated.