中文摘要：

目的探讨五昧子乙素对大鼠胶质瘤生长的作用机制。方法建立Wistar大鼠胶质瘤模型，用200mg／kg五味子乙素灌胃处理7d，实验结束后取出肿瘤，测定肿瘤的重量和体积，检测大鼠血清中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的活力和谷胱甘肽的含量。结果五味子乙素可明显抑制胶质瘤的生长，用药组肿瘤体积较对照组肿瘤体积明显缩小（P〈0．05）；用药组肿瘤重量较对照组亦明显减少（P〈0．05），药物组大鼠白清谷胱甘肽（GSH），SOD、CAT有所下降，与对照组相比具有统计学意义（P〈0．05）。结论五味子乙素通过影响胶质瘤大鼠血清中氧化应激指标，可以显著地发挥抑制胶质瘤生长的作用。

英文摘要：

Objective To establish the glioma model of rats, explore the effect of Schisandrin B on the growth of glioma in rats. Methods The glioma model of Wistar rats were established, and then were treated with 200 mg/kg Sehisandrin B by intragastrie ad-ministration for 7 d, the tumors were removed, and the volume and weight of tumors were examined, the levels of superoxide dismutase （SOD）, glutathione（GLU） and eatalase（CAT） in scum were detected. Results Sehisandrin B inhibited the growth of gliomas, the volume of tumors in drug group [ （47.10 ± 45.12） mm^3]was significantly decreased compared with that of control group [ （ 139.90 ± 74.87） mm^3 ] （ P 〈 0.05 ） ; the weitht of tumors in drug group [ （ 0.12 ± 0.10 ） g ] was significantly decreased than that of control group [ （ 0.15 ± 0.06 ） g] （ P 〈 0.05 ） ; the level of SOD, GLU and CAT in serum of rats were decreased than those of control group （ P 〈 0.05 ）. Conclusions Sehisandrin B could inhibit the growth of glioma in rats by regulating the level of oxidative stress factors.