Baculoviridae 是对节肢动物只病原的包的脱氧核糖核酸病毒的一个大家庭。Baculoviruses 广泛地在昆虫被使用了基于房间的重组体蛋白质表达式系统;同样生物的杀虫剂。他们是 deomostrated 对哺乳动物安全,鸟;鱼。最近,尽管有他们不能在哺乳动物的房间复制的事实, baculoviruses 被看了不同哺乳动物的房间到 transduce (11, 73, 76 ) 。这作为哺乳动物的表达式系统导致了 baculoviruses 的开发;甚至作为为基因治疗的背心 ors。
The Baculoviridae are a large family of enveloped DNA viruses exclusively pathogenic to arthropods. Baculoviruses have been extensively used in insect cell-based recombinant protein expression system and as biological pesticides. They have been deomostrated to be safe to mammals, birds and fish. Recently, baculoviruses has been shown to transduce different mammalian cells in spite of the fact that they cannot replicate in mammalian cells (11, 73, 76). This has resulted in the development of baculoviruses as mammalian expression systems and even as vestors for gene therapy.