中文摘要：

瞄准：到学习， Zusanli 或 Liangmeng 上的艾灸的效果在有热吃惊蛋白质 70 的表示(HSP70 ) 的导致压力的溃疡老鼠和它的关联在胃粘膜损害上指向。方法：六十只健康 SD 老鼠(30 男性， 30 女性) 被划分成控制组，损害模型组， Zushanli 点组， Liangmeng 点组。压力胃溃疡模型被有约束力的冷压力方法劝诱。胃粘膜溃疡损害(UI ) 索引被 Guth 方法计算。胃粘膜血流(GMBF ) 与一个生物信号分析器被记录。在胃的粘膜 HSP70 的蛋白质内容和基因表示被免疫组织化学(IHC ) 和反向的抄写聚合酶链反应(RT-PCR ) 检测。硫巴比妥方法被用来决定 malondialdehyde (MDA ) 内容。胃的粘膜 endothelin (et ) 和前列腺素Ｅ－２(PGE2 ) 被放射性免疫测定分析。结果：高胃的粘膜 UI 索引，高 HSP70 表示，低 GMBF 和 PGF2，提高的 MDA 和 et 在受到冷应力的老鼠的胃粘膜被观察。Zusanli 或 Liangmeng 上的艾灸削尖减少的老鼠胃的粘膜 UI 索引， MDA 和 et 相反地， HSP70， GMBF，和 PGE2 的表示在 Zusanli 上与艾灸在预告的处理以后在胃粘膜被提高或 Liangmeng 指。观察参数在 Zusanli 和 Liangmeng 点之间是显著地不同的。结论：有 Zusanli 或 Liangmeng 点上的艾灸的预告的处理保护胃粘膜免于压力损害。这保护与 HSP70 mRNA 和蛋白质的更高的表示被联系，导致 PGE2 的版本和 MDA 和 et 的抑制，胃的粘膜的缺陷索引。

英文摘要：

AIM： To study the effect of moxibustion on Zusanli or Liangmeng point on gastric mucosa injury in stressinduced ulcer rats and its correlation with the expression of heat shock protein 70 （HSP70）. METHODS： Sixty healthy SD rats （30 males, 30 females） were divided into control group, injury model group, Zushanli point group, Liangmeng point group. Stress gastric ulcer model was induced by binding cold stress method. Gastric mucosa ulcer injury （UI） index was calculated by Guth method. Gastric mucosa blood flow （GMBF） was recorded with a biological signal analyzer. Protein content and gene expression in gastric mucosal HSP70 were detected by immunohistochemistry （IHC） and reverse transcription polymerase chain reaction （RT-PCR）. Thiobarbital method was used to determine malondialdehyde （MDA） content. Gastric mucosal endothelin （ET） and prostaglandin E2 （PGE2） were analyzed by radioimmunoassay. RESULTS： High gastric mucosal UI index, high HSP70 expression, low GMBF and PGF2, elevated MDA and ET were observed in gastric mucosa of rats subjected to cold stress. Moxibustion on Zusanli or Liangmeng point decreased rat gastric mucosal UI index, MDA and ET. Conversely, the expression of HSP70, GMBF, and PGE2 was elevated in gastric mucosa after pretreatment with moxibustion on Zusanli or Liangmeng point. The observed parameters were significantly different between Zusanli and Liangmeng points. CONCLUSION： Pretreatment with moxibustion on Zusanli or Liangmeng point protects gastric mucosa against stress injury. This protection is associated with the higher expression of HSP70 mRNA and protein, leading to release of PGE2 and inhibition of MDA and ET, impairment of gastric mucosal index.