中文摘要：

采用共沉淀法在水相中合成表面修饰氨基的磁性纳米粒子（MNPs）,进一步在其表面接枝叶酸（FA）修饰的β-环糊精衍生物（β-CDs）,制得一种新型药物载体材料（FA-β-CDs-MNPs）,并通过核磁共振光谱（1 H NMR）、红外光谱（FTIR）进行了结构表征。透射电镜（TEM）、X-射线衍射（XRD）、磁性能（VSM）分析表明：该纳米复合材料的尺寸为16nm左右,近似圆形且分散性能良好,用振动磁强计测得其具有超顺磁性,饱和磁化率为58emu/g,是潜在的肿瘤细胞靶向型药物载体材料。

英文摘要：

A novel MNPs-based nanoparticle drug delivery system（DDS）was assembled and characterized.MNPs were prepared according to chemical co-precipitation method.After amination with amino silane coupling agent,folic acid modifiedβ-CDs were grafted onto the surface of magnetic nanoparticles.The morphology and properties of obtained nanoparticles were characterized by nuclear magnetic resonance（1 H NMR）,Fourier transform infrared spectroscopy（FT-IR）,transmission electron microscopy（TEM）,Xray powder diffraction（XRD）,and vibrating sample magnetometer（VSM）.TEM images showed that the size of nanoparticles was about 16 nm.The FA-β-CD-MNPs exhibited relatively high saturation magnetization.These results suggested the newly developed magnetic hybrid nanomaterial has potential applications as the drug carrier.